Succinate metabolism: a promising therapeutic target for inflammation, ischemia/reperfusion injury and cancer

Succinate serves as an essential circulating metabolite within the tricarboxylic acid (TCA) cycle and functions a substrate for succinate dehydrogenase (SDH), thereby contributing to energy production in fundamental mitochondrial metabolic pathways. Aberrant changes concentrations have been associated with pathological states, including chronic inflammation, ischemia/reperfusion (IR) injury, cancer, resulting from exaggerated response of specific immune cells, rendering it central area investigation. Recent studies elucidated pivotal involvement SDH immunity beyond processes, particularly context cancer. Current scientific endeavors are concentrated on comprehending functional repercussions modifications, specifically pertaining SDH, cells operating hypoxic milieu. The efficacy targeting alterations manipulate cell hypoxia-related diseases demonstrated. Consequently, comprehensive understanding succinate’s role metabolism regulation is crucial effectively therapeutic interventions influence progression diseases. This review provides succinct overview latest advancements emerging processes. Furthermore, explores succinate, intermediary TCA cycle, IR particular emphasis mechanisms underlying accumulation. critically assesses potential modulating accumulation milieu means combat various It targets by focusing disorders.